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    MicroRNA/mRNA regulatory networks in the control of skin development and regeneration.

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    Publication date
    2012
    Author
    Botchkareva, Natalia V.
    Keyword
    Skin development; Skin regeneration; MicroRNA/mRNA regulatory networks; Gene activation; Gene silencing
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Skin development, postnatal growth and regeneration are governed by complex and well-balanced programs of gene activation and silencing. The crosstalk between small non-coding microRNAs (miRNAs) and mRNAs is highly important for steadiness of signal transduction and transcriptional activities as well as for maintenance of homeostasis in many organs, including the skin. Recent data demonstrated that the expression of many genes, including cell type-specific master transcription regulators implicated in the control of skin development and homeostasis, is regulated by miRNAs. In addition, individual miRNAs could mediate the effects of these signaling pathways through being their downstream components. In turn, the expression of a major constituent of the miRNA processing machinery, Dicer, can be controlled by cell type-specific transcription factors, which form negative feedback loop mechanisms essential for the proper execution of cell differentiation- associated gene expression programs and cell-cell communications during normal skin development and regeneration. This review summarizes the available data on how miRNA/mRNA regulatory networks are involved in the control of skin development, epidermal homeostasis, hair cycle-associated tissue remodeling and pigmentation. Understanding of the fundamental mechanisms that govern skin development and regeneration will contribute to the development of new therapeutic approaches for many pathological skin conditions by using miRNA-based interventions.
    URI
    http://hdl.handle.net/10454/7223
    Version
    No full-text available in the repository
    Citation
    Botchkareva NV (2012) MicroRNA/mRNA regulatory networks in the control of skin development and regeneration. Cell Cycle. 11 (3):468-74.
    Link to publisher’s version
    http://dx.doi.org/10.4161/cc.11.3.19058
    Type
    Article
    Collections
    Life Sciences Publications

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