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dc.contributor.authorLiu, B.*
dc.contributor.authorLiu, Y.F.*
dc.contributor.authorDu, Y.R.*
dc.contributor.authorMardaryev, Andrei N.*
dc.contributor.authorYang, W.*
dc.contributor.authorChen, H.*
dc.contributor.authorXu, Z.M.*
dc.contributor.authorXu, C.Q.*
dc.contributor.authorZhang, X.R.*
dc.contributor.authorBotchkarev, Vladimir A.*
dc.contributor.authorZhang, Y.*
dc.contributor.authorXu, G.L.*
dc.date.accessioned2015-06-03T11:28:30Z
dc.date.available2015-06-03T11:28:30Z
dc.date.issued2013
dc.identifier.citationLiu B, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ, Zhang XR, Botchkarev VA, Zhang Y and Xu GL (2013) Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 140 (4): 780-8.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7222
dc.descriptionnoen_US
dc.description.abstractThymic epithelial cells (TECs) are the main component of the thymic stroma, which supports T-cell proliferation and repertoire selection. Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an essential and non-redundant role in thymic organogenesis. Targeted disruption of Cbx4 causes severe hypoplasia of the fetal thymus as a result of reduced thymocyte proliferation. Cell-specific deletion of Cbx4 shows that the compromised thymopoiesis is rooted in a defective epithelial compartment. Cbx4-deficient TECs exhibit impaired proliferative capacity, and the limited thymic epithelial architecture quickly deteriorates in postnatal mutant mice, leading to an almost complete blockade of T-cell development shortly after birth and markedly reduced peripheral T-cell populations in adult mice. Furthermore, we show that Cbx4 physically interacts and functionally correlates with p63, which is a transcriptional regulator that is proposed to be important for the maintenance of the stemness of epithelial progenitors. Together, these data establish Cbx4 as a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1242/dev.085035en_US
dc.subjectThymic epithelial cell; Cbx4; Thymic hypoplasia; T-lymphopoiesis; p63 (Trp63); Polycomb; Epithelial progenitoren_US
dc.subjectREF 2014
dc.titleCbx4 regulates the proliferation of thymic epithelial cells and thymus function.en_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US


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