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dc.contributor.authorKohwi-Shigematsu, T.*
dc.contributor.authorPoterlowicz, Krzysztof*
dc.contributor.authorOrdinario, E.*
dc.contributor.authorHan, H.J.*
dc.contributor.authorBotchkarev, Vladimir A.*
dc.contributor.authorKohwi, Y.*
dc.date.accessioned2015-06-03T11:18:21Z
dc.date.available2015-06-03T11:18:21Z
dc.date.issued2013
dc.identifier.citationKohwi-Shigematsu T, Poterlowicz K, Ordinario E, Han HJ, Botchkarev VA and Kohwi Y (2013) Genome organizing function of SATB1 in tumor progression. Seminars in Cancer Biology, 23 (2): 72-9.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7220
dc.descriptionnoen_US
dc.description.abstractWhen cells change functions or activities (such as during differentiation, response to extracellular stimuli, or migration), gene expression undergoes large-scale reprogramming, in cell type- and function-specific manners. Large changes in gene regulation require changes in chromatin architecture, which involve recruitment of chromatin remodeling enzymes and epigenomic modification enzymes to specific genomic loci. Transcription factors must also be accurately assembled at these loci. SATB1 is a genome organizer protein that facilitates these processes, providing a nuclear architectural platform that anchors hundreds of genes, through its interaction with specific genomic sequences; this activity allows expression of all these genes to be regulated in parallel, and enables cells to thereby alter their function. We review and describe future perspectives on SATB1 function in higher-order chromatin structure and gene regulation, and its role in metastasis of breast cancer and other tumor types.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.semcancer.2012.06.009en_US
dc.subjectSATB1; Chromatin structure; Cancer metastasis; Gene regulation; Nuclear architecture; Epigenetics; Tumor progressionen_US
dc.titleGenome organizing function of SATB1 in tumor progression.en_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US


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