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dc.contributor.authorGruber, J.V.
dc.contributor.authorHoltz, R.
dc.contributor.authorSikkink, Stephen K.
dc.contributor.authorTobin, Desmond J.
dc.date.accessioned2015-01-27T09:32:01Z
dc.date.available2015-01-27T09:32:01Z
dc.date.issued2014
dc.identifier.citationGruber, J.V., Holtz, R., Sikkink, S.K., Tobin, D.J., (2014) In vitro and ex vivo examination of topical Pomiferin treatments. Fitoterapia, 94:164-71.en_US
dc.identifier.urihttp://hdl.handle.net/10454/7061
dc.descriptionnoen_US
dc.description.abstractPomiferin is a unique, prenylated isoflavonoid that can be isolated and purified from the fruits of Maclura pomifera (Osage Orange). The molecule typically is isolated with a small amount of a molecule called Osajin which is structurally similar to Pomiferin but lacks an aromatic hydroxyl group. As a consequence, Osajin has been shown to be a less effective antioxidant than Pomiferin. In vitro studies on Normal Human Dermal Fibroblasts demonstrate that Pomiferin is a potent extracellular matrix protein stimulant, showing increases in collagen, elastin and fibrillin expression comparable or superior to equivalent concentrations of retinol. Ex vivo hair follicle assays demonstrate comparable effects on expression of collagen and elastin at Pomiferin concentrations in the range of 0.05–5 ppm. Taken together, the results from the two assays conducted on different models indicate that Pomiferin may be a very interesting ingredient for topical skin and scalp treatments where modulation of the expression of extracellular matrix proteins is important.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/ 10.1016/j.fitote.2014.01.023en_US
dc.subjectMaclura pomifera; Osage Orange; Pomiferin; Antioxidant; Matrix proteins; Follicle; Topical skin treatment; Human hair; Dermal treatmenten_US
dc.titleIn vitro and ex vivo examination of topical Pomiferin treatment.en_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionpublished version paperen_US


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