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dc.contributor.authorWittmann, Miriam*
dc.contributor.authorMcGonagle, D.*
dc.contributor.authorWerfel, T.*
dc.date.accessioned2014-12-19T10:33:04Z
dc.date.available2014-12-19T10:33:04Z
dc.date.issued2014
dc.identifier.citationWittmann, M., McGonagle, D. and Werfel, T. (2014) Cytokines as therapeutic targets in skin inflammation. Cytokine Growth Factor Review, 25 (4) 443-51en_US
dc.identifier.urihttp://hdl.handle.net/10454/6833
dc.descriptionnoen_US
dc.description.abstractThis review focuses on treatment targets for the most common inflammatory skin diseases, eczema and psoriasis with an emphasis on cytokines expressed in the uppermost layer of the skin which is easily accessible for diagnostic and therapeutic approaches. Recently, a significant body of research has highlighted the influence of the skin barrier and the patients’ microbiome on skin inflammatory responses and we will comment on their impact on mediator regulation. Itch is a prominent dermatology symptom which is influenced by cytokines and can via itch–scratch cycle impact on the skin barrier and mediator expression associated with damage. Taking the contribution of pruritus and superficial skin damage into account, we address cytokines as targets for stratified treatment approaches in subgroups of eczema and psoriasis.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://www.sciencedirect.com/science/article/pii/S1359610114000707en_US
dc.subjectPsoriasis; Atopic dermatitis; Antimicrobial peptides; Microbiome; Pruritus; Keratinocytes: Skin inflammatory responsesen_US
dc.titleCytokines as therapeutic targets in skin inflammationen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US


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