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dc.contributor.authorBotchkarev, Vladimir A.*
dc.contributor.authorFlores, E.R.*
dc.date.accessioned2014-12-19T10:32:19Z
dc.date.available2014-12-19T10:32:19Z
dc.date.issued2014
dc.identifier.citationBotchkarev VA and Flores ER (2014) p53/p63/p73 in the epidermis in health and disease. Cold Spring Harbour Perspectives in Medicine. 4(8): a015248.
dc.identifier.urihttp://hdl.handle.net/10454/6832
dc.descriptionNo
dc.description.abstractAlthough p53 has long been known as the “guardian of the genome” with a role in tumor suppression in many tissues, the discovery of two p53 ancestral genes, p63 and p73, more than a decade ago has triggered a considerable amount of research into the role of these genes in skin development and diseases. In this review, we primarily focus on mechanisms of action of p53 and p63, which are the best-studied p53 family members in the skin. The existence of multiple isoforms and their roles as transcriptional activators and repressors are key to their function in multiple biological processes including the control of skin morphogenesis, regeneration, tumorigenesis, and response to chemotherapy. Last, we provide directions for further research on this family of genes in skin biology and pathology.
dc.language.isoen
dc.subjectp53
dc.subjectp63
dc.subjectp73
dc.subjectGenes
dc.subjectEpidermis
dc.subjectSkin health
dc.subjectSkin disease
dc.subjectSkin pathology
dc.titlep53/p63/p73 in the Epidermis in Health and Disease
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1101/cshperspect.a015248
dc.openaccess.statusclosedAccess


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