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dc.contributor.authorAhmed, Mohammed I.*
dc.contributor.authorAlam, Majid A.*
dc.contributor.authorEmelianov, V.U.*
dc.contributor.authorPoterlowicz, Krzysztof*
dc.contributor.authorPatel, Ankit*
dc.contributor.authorSharov, A.A.*
dc.contributor.authorMardaryev, Andrei N.*
dc.contributor.authorBotchkareva, Natalia V.*
dc.date.accessioned2014-12-09T14:42:23Z
dc.date.available2014-12-09T14:42:23Z
dc.date.issued2014
dc.identifier.citationAhmed MI, Alam M, Emelianov VU et al (2014) MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. Journal of Cell Biology. 207(4): 549-67.en_US
dc.identifier.urihttp://hdl.handle.net/10454/6727
dc.descriptionYesen_US
dc.description.abstractSkin development is governed by complex programs of gene activation and silencing, including microRNA-dependent modulation of gene expression. Here, we show that miR-214 regulates skin morphogenesis and hair follicle (HF) cycling by targeting β-catenin, a key component of the Wnt signaling pathway. miR-214 exhibits differential expression patterns in the skin epithelium, and its inducible overexpression in keratinocytes inhibited proliferation, which resulted in formation of fewer HFs with decreased hair bulb size and thinner hair production. The inhibitory effects of miR-214 on HF development and cycling were associated with altered activities of multiple signaling pathways, including decreased expression of key Wnt signaling mediators β-catenin and Lef-1, and were rescued by treatment with pharmacological Wnt activators. Finally, we identify β-catenin as one of the conserved miR-214 targets in keratinocytes. These data provide an important foundation for further analyses of miR-214 as a key regulator of Wnt pathway activity and stem cell functions during normal tissue homeostasis, regeneration, and aging.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1083/jcb.201404001en_US
dc.rights© 2014 Ahmed et al. This is an Open Access article under the Creative Commons Attribution–Noncommercial–Share Alike license (http://creativecommons.org/licenses/by-nc-sa/3.0/)
dc.subjectHair folliclesen_US
dc.subject; Skin developmenten_US
dc.subject; MicroRNA-214en_US
dc.subject; Wnt pathwayen_US
dc.titleMicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathwayen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US


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