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    MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway

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    Publication date
    2014
    Author
    Ahmed, Mohammed I.
    Alam, Majid A.
    Emelianov, V.U.
    Poterlowicz, Krzysztof
    Patel, Ankit
    Sharov, A.A.
    Mardaryev, Andrei N.
    Botchkareva, Natalia V.
    Keyword
    Hair follicles
    ; Skin development
    ; MicroRNA-214
    ; Wnt pathway
    Rights
    © 2014 Ahmed et al. This is an Open Access article under the Creative Commons Attribution–Noncommercial–Share Alike license (http://creativecommons.org/licenses/by-nc-sa/3.0/)
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Skin development is governed by complex programs of gene activation and silencing, including microRNA-dependent modulation of gene expression. Here, we show that miR-214 regulates skin morphogenesis and hair follicle (HF) cycling by targeting β-catenin, a key component of the Wnt signaling pathway. miR-214 exhibits differential expression patterns in the skin epithelium, and its inducible overexpression in keratinocytes inhibited proliferation, which resulted in formation of fewer HFs with decreased hair bulb size and thinner hair production. The inhibitory effects of miR-214 on HF development and cycling were associated with altered activities of multiple signaling pathways, including decreased expression of key Wnt signaling mediators β-catenin and Lef-1, and were rescued by treatment with pharmacological Wnt activators. Finally, we identify β-catenin as one of the conserved miR-214 targets in keratinocytes. These data provide an important foundation for further analyses of miR-214 as a key regulator of Wnt pathway activity and stem cell functions during normal tissue homeostasis, regeneration, and aging.
    URI
    http://hdl.handle.net/10454/6727
    Version
    Published version
    Citation
    Ahmed MI, Alam M, Emelianov VU et al (2014) MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. Journal of Cell Biology. 207(4): 549-67.
    Link to publisher’s version
    http://dx.doi.org/10.1083/jcb.201404001
    Type
    Article
    Collections
    Life Sciences Publications

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