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    Long non‑coding RNAs drive metastatic progression in melanoma (Review)

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    Publication date
    2014
    Author
    Akhbari, Pouria
    Whitehouse, A.
    Boyne, James R.
    Keyword
    Metastatic melanoma
    ; RNA
    ; Skin-cancer
    ; NGS
    ; Non-coding genomic transcripts
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Metastatic melanoma is the leading cause of skin‑cancer related deaths and while in recent years some progress has been made with targeted therapies, there remains an urgent unmet need for novel therapeutic treatments and reliable diagnostic, prognostic and predictive biomarkers. The emergence of next generation sequencing (NGS) has seen a growing appreciation for the role played by non‑coding genomic transcripts in regulating gene expression and by extension impacting on disease progression. The long non‑coding RNAs (lncRNAs) represent the most enigmatic of these new regulatory molecules. Our understanding of how lncRNAs regulate biological functions and their importance to disease aetiology, while still limited, is rapidly improving, in particular with regards to their role in cancer. Herein we review the identification of several lncRNAs shown to impact on melanoma disease progression and discuss how these molecules are operating at the molecular level.
    URI
    http://hdl.handle.net/10454/6705
    Version
    No full-text available in the repository
    Citation
    Akhbari P, Whitehouse A, and Boyne JR (2014) Long non‑coding RNAs drive metastatic progression in melanoma (Review). International Journal of Oncology. 45(6): 2181-2186.
    Link to publisher’s version
    http://dx.doi.org/10.3892/ijo.2014.2691
    Type
    Article
    Collections
    Life Sciences Publications

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