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    The Highest Mountain – T- Cell Technology

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    BJHCM The Highest Mountain T- Cell Technology.pdf (314.7Kb)
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    Publication date
    2014
    Author
    McIntosh, Bryan
    Fascia, M.
    Keyword
    Cancer; Leukaemia; T-cells; Immunosuppression; T-cell receptor; TCR
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    T-lymphocytes (T-cell) therapy offers a treatment for cancers. Developing this technology in the future provides the opportunity to revolutionise treatment and to make cancer a chronic condition. T-cells in themselves are a type of lymphocytes (itself a type of white blood cell) that play a central role in cell mediated immunity. They can be distinguished from other lymphocytes, such as B-cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. T-cells have the capacity to destroy diseased cells, but tumours present a considerable challenge that reduces their impact. As cancer cells are frequently ‘invisible’ to the immune system, and they create an environment that suppresses T-cell activity., genetic engineering of T-cells can be used therapeutically to overcome these challenges. T-cells can be taken from the blood of cancer patients and then modified to recognise and destroy cancer-specific antigens.
    URI
    http://hdl.handle.net/10454/6600
    Version
    Accepted Manuscript
    Citation
    McIntosh B and Fascia M (2014) The Highest Mountain – T- Cell Technology. British Journal of Healthcare Management. 20(6): 281–285.
    Link to publisher’s version
    http://www.magonlinelibrary.com/doi/abs/10.12968/bjhc.2014.20.6.281
    Type
    Article
    Collections
    Health Studies Publications

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