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dc.contributor.authorPapageorgiou, Nikolaos*
dc.contributor.authorCarpenter, Elizabeth*
dc.contributor.authorScally, Andy J.*
dc.contributor.authorTobin, Desmond J.*
dc.date.accessioned2014-07-08T17:19:25Z
dc.date.available2014-07-08T17:19:25Z
dc.date.issued2008
dc.identifier.citationPapageorgiou, N., Carpenter, E., Scally, A. J. and Tobin, D. J. (2008) Adult human epidermal melanocytes for neurodegeneration research. Neuroreport, 19 (18), 1787-91.en_US
dc.identifier.urihttp://hdl.handle.net/10454/6387
dc.description.abstractNeuronal models for Alzheimer's disease research frequently have limitations as a result of their nonhuman origin and/or transformed state. Here we examined the potential of readily accessible neural crest-derived human epidermal melanocytes isolated from elderly individuals as a model system for Alzheimer's disease research. The amyloidogenic isoforms of amyloid precursor protein (APP; isoforms APP751/770) and amyloid beta (A¿)1¿40 were detected in epidermal melanocytes using immunocytochemistry and western blotting. Incubation of epidermal melanocytes with aggregated A¿1¿40 peptide caused a concentration-dependent reduction in cell viability, whereas age-matched dermal fibroblasts remained unaffected. These findings suggest that epidermal melanocytes from elderly donors are capable of amyloidogenesis and are sensitive to A¿1¿40 cytotoxicity. Thus, these cells may provide a readily accessible human cell model for Alzheimer's disease research.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1097/WNR.0b013e3283193e82en_US
dc.subjectNeural crest-derived human epidermal melanocytesen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectNeuronal modelsen_US
dc.subjectAmyloid precursor protein (APP)en_US
dc.titleAdult human epidermal melanocytes for neurodegeneration research.en_US
dc.status.refereedn/aen_US
dc.typeArticleen_US
dc.type.versionpublished version paperen_US


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