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dc.contributor.authorBruce, Alison*
dc.contributor.authorPacey, Ian E.*
dc.contributor.authorDharni, Poonam*
dc.contributor.authorScally, Andy J.*
dc.contributor.authorBarrett, Brendan T.*
dc.date.accessioned2014-07-02T10:40:02Z
dc.date.available2014-07-02T10:40:02Z
dc.date.issued2009
dc.identifier.citationBruce, A., Pacey, I. E., Dharni, P., Scally, A. J. and Barrett, B. T. (2009) Repeatability and reproducibility of Macular Thickness Measurements Using Fourier Domain Optical Coherence Tomography. The Open Ophthalmology Journal, 2009, 3, 10-14en_US
dc.identifier.urihttp://hdl.handle.net/10454/6384
dc.description.abstractAim: To evaluate repeatability and reproducibility of macular thickness measurements in visually normal eyes using the Topcon 3D OCT-1000. Methods: Phase 1 investigated scan repeatability, the effect of age and pupil dilation. Two groups (6 younger and 6 older participants) had one eye scanned 5 times pre and post- dilation by 1 operator. Phase 2 investigated between-operator, within and between-visit reproducibility. 10 participants had 1 un-dilated eye scanned 3 times on 2 separate visits by 2 operators. Results: Phase 1: No significant difference existed between repeat scans (p=0.75) and no significant difference was found pre- and post-dilation (p=0.54). In the younger group variation was low (95% limits ± 3.62 m) and comparable across all retinal regions. The older group demonstrated greater variation (95% limits ± 7.6 m). Phase 2: For a given retinal location, 95% confidence limits for within-operator, within-visit reproducibility was 5.16 m. This value increased to 5.56 m for the same operator over two visits and to 6.18 m for two operators over two visits. Conclusion: A high level repeatability, close to 6 m, of macular thickness measurement is possible using the 3D OCT- 1000. Measured differences in macular thickness between successive visits that exceed 6 m in pre-presbyopic individuals are therefore likely to reflect actual structural change. OCT measures are more variable in older individuals and it is advisable to take a series of scans so that outliers can be more easily identified.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.2174/1874364100903010010en_US
dc.subjectOptical coherence tomography, Retinal thickness, Macula, Image analysis, Repeatability, Reproducibility.en_US
dc.titleRepeatability and reproducibility of Macular Thickness Measurements Using Fourier Domain Optical Coherence Tomographyen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionpublished version paperen_US


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