Browsing Life Sciences Publications by Subject "(η6-arene)-ruthenium; Anticancer agents; η5-C5(CH3)4R ruthenium complexes"
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Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligandsThe complexes [RuCp*(PP)Cl] (Cp* = C5Me5; , PP = dppm; , PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; , PP = dppm; , PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6]  were synthesized and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.