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dc.contributor.authorWheelhouse, Richard T.*
dc.contributor.authorGarbett, N.C.*
dc.contributor.authorBuurma, N.J.*
dc.contributor.authorChaires, J.B.*
dc.date.accessioned2014-04-28T11:27:07Z
dc.date.available2014-04-28T11:27:07Z
dc.date.issued2010-03-29
dc.identifier.citationWheelhouse RT, Garbett NC, Buurma NJ and Chaires JB (2010) Probing the molecular recognition of a DNA-RNA hybrid duplex. Angewandte Chemie International Edition. 49(18): 3207-3210.en
dc.identifier.urihttp://hdl.handle.net/10454/6233
dc.descriptionYesen
dc.description.abstractCuriouser and curiouser! A biarylpyrimidine ligand (see picture: N blue, H cyan, S yellow) shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.en
dc.relation.isreferencedbyhttp://dx.doi.org/10.1002/anie.200907235
dc.rights© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Full-text reproduced in accordance with the publisher’s self-archiving policy. This is the peer-reviewed version of the following article: Wheelhouse RT, Garbett NC, Buurma NJ and Chaires JB (2010) Probing the Molecular Recognition of a DNA·RNA Hybrid Duplex. Angewandte Chemie. 49(18): 3207-3210, which has been published in final form at http://dx.doi.org/10.1002/anie.200907235. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archivingen
dc.subjectDNA; Chemistry;
dc.subjectLigands;
dc.subjectMolecular Probes;
dc.subjectMolecular structure;
dc.subjectNucleic Acid Hybridization;
dc.subjectPoly A;
dc.subjectPoly U;
dc.subjectRNA;
dc.subjectREF 2014
dc.titleProbing the molecular recognition of a DNA-RNA hybrid duplex
dc.status.refereedYesen
dc.typeArticle
dc.type.versionAccepted Manuscripten
refterms.dateFOA2018-07-19T10:47:16Z


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