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Publication date
29/03/2010Keyword
DNAChemistry
Ligands
Molecular Probes
Molecular structure
Nucleic Acid Hybridization
Poly A
Poly U
RNA
REF 2014
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© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Full-text reproduced in accordance with the publisher's self-archiving policy. This is the peer-reviewed version of the following article: Wheelhouse RT, Garbett NC, Buurma NJ and Chaires JB (2010) Probing the Molecular Recognition of a DNA·RNA Hybrid Duplex. Angewandte Chemie. 49(18): 3207-3210, which has been published in final form at http://dx.doi.org/10.1002/anie.200907235. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-ArchivingPeer-Reviewed
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openAccess
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Show full item recordAbstract
Curiouser and curiouser! A biarylpyrimidine ligand (see picture: N blue, H cyan, S yellow) shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.Version
Accepted manuscriptCitation
Wheelhouse RT, Garbett NC, Buurma NJ and Chaires JB (2010) Probing the molecular recognition of a DNA-RNA hybrid duplex. Angewandte Chemie International Edition. 49(18): 3207-3210.Link to Version of Record
https://doi.org/10.1002/anie.200907235Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1002/anie.200907235