Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins
Publication date
2013Author
Travica, S.Pors, Klaus
Loadman, Paul

Shnyder, Steven D.
Johansson, I.
Alandas, Mohammed N.
Sheldrake, Helen M.
Mkrtchian, S.
Patterson, Laurence H.
Ingelman-Sundberg, M.
Keyword
Animals; Bystander effect
; Cell line; Tumor
; Colonic neoplasms; Enzymology; Genetics; Pathology
; Cytochrome P-450 enzyme system; Metabolism
; Cytotoxins; Pharmacokinetics; Toxicity
; DNA damage; Drug effects
; Drug resistance, Neoplasm
; Female
; Gene expression
; Heterocyclic compounds; 3-Ring
; Humans
; Indoles
; Mice
; Tissue distribution
; Tumor burden
; Xenograft model antitumor assays
; REF 2014