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dc.contributor.authorStewart-Knox, Barbara*
dc.contributor.authorRae, G.*
dc.contributor.authorSimpson, E.E.A.*
dc.contributor.authorMcConville, C.*
dc.contributor.authorO'Connor, J.M.*
dc.contributor.authorPolito, A.*
dc.contributor.authorAndriollo-Sanchez, M.*
dc.contributor.authorCoudray, C.*
dc.contributor.authorStrain, J.J.*
dc.date.accessioned2014-04-28T11:21:24Z
dc.date.available2014-04-28T11:21:24Z
dc.date.issued2011
dc.identifier.citationStewart-Knox, B. J., Rae, G., Simpson, E. E., McConville, C., O'Connor, J., Polito, A., Andriollo-Sanchez, M., Coudray, C., Strain, J. J. (2011) Supplemented zinc does not alter mood in healthy older European adults - a randomised placebo-controlled trial: the Zenith study. Public Health Nutrition, 14(5), 882-888.
dc.identifier.sici90026338
dc.identifier.urihttp://hdl.handle.net/10454/6207
dc.description.abstractOBJECTIVE: Older people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans. SUBJECTS: Healthy volunteers (n 387) aged 55-87 years were recruited. SETTING: Volunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70-87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55-70 years. DESIGN: Mood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention. RESULTS: Mixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55-70 years or the >/=70 years age group. CONCLUSIONS: These results suggest that zinc does not benefit mood in healthy older people.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1017/S1368980010002764
dc.subjectAffect; Drug effects
dc.subjectAged
dc.subject80 and over
dc.subjectDietary supplements
dc.subjectDouble-blind method
dc.subjectEurope
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle aged
dc.subjectTrace elements; Administration & dosage; Blood; Deficiency; Pharmacology
dc.subjectZinc
dc.subjectREF 2014
dc.titleSupplemented zinc does not alter mood in healthy older European adults - a randomised placebo-controlled trial: the Zenith study
dc.typeArticle


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