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dc.contributor.authorRasmussen, M.*
dc.contributor.authorLi, Y.*
dc.contributor.authorLindgreen, S.*
dc.contributor.authorPedersen, J.S.*
dc.contributor.authorAlbrechtsen, A.*
dc.contributor.authorMoltke, I.*
dc.contributor.authorMetspalu, M.*
dc.contributor.authorMetspalu, E.*
dc.contributor.authorKivisild, T.*
dc.contributor.authorGupta, R.*
dc.contributor.authorBertalan, M.*
dc.contributor.authorNielsen, K.*
dc.contributor.authorGilbert, M.T.P.*
dc.contributor.authorWang, Y.*
dc.contributor.authorRaghavan, M.*
dc.contributor.authorCampos, P.F.*
dc.contributor.authorKamp, H.M.*
dc.contributor.authorWilson, Andrew S.*
dc.contributor.authorGledhill, Andrew R.*
dc.contributor.authorTridico, S.*
dc.contributor.authorBunce, M.*
dc.contributor.authorLorenzen, E.D.*
dc.contributor.authorBinladen, J.*
dc.contributor.authorGuo, X.*
dc.contributor.authorZhao, J.*
dc.contributor.authorZhang, X.*
dc.contributor.authorZhang, H.*
dc.contributor.authorLi, Z.*
dc.contributor.authorChen, M.*
dc.contributor.authorOrlando, L.*
dc.contributor.authorKristiansen, K.*
dc.contributor.authorBak, M.*
dc.contributor.authorTommerup, N.*
dc.contributor.authorBendixen, C.*
dc.contributor.authorPierre, T.L.*
dc.contributor.authorGronnow, B.*
dc.contributor.authorMeldgaard, M.*
dc.contributor.authorAndreasen, C.*
dc.contributor.authorFedorova, S.A.*
dc.contributor.authorOsipova, L.P.*
dc.contributor.authorHigham, T.F.G.*
dc.contributor.authorRamsey, C.B.*
dc.contributor.authorHansen, T.v.O.*
dc.contributor.authorNielsen, F.C.*
dc.contributor.authorCrawford, M.H.*
dc.contributor.authorBrunak, S.*
dc.contributor.authorSicheritz-Ponten, T.*
dc.contributor.authorVillems, R.*
dc.contributor.authorNielsen, R.*
dc.contributor.authorKrogh, A.*
dc.contributor.authorWang, J.*
dc.contributor.authorWillerslev, E.*
dc.date.accessioned2014-04-28T11:14:26Z
dc.date.available2014-04-28T11:14:26Z
dc.date.issued2010
dc.identifier.citationRasmussen M, Li Y, Lindgreen ST et al (2010) Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature. 463(7282): 757-62.
dc.identifier.urihttp://hdl.handle.net/10454/6149
dc.descriptionNo
dc.description.abstractWe report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1038/nature08835
dc.subjectCryopreservation
dc.subject; Emigration; Immigration
dc.subject; Extinction
dc.subject; Genetics; Population
dc.subject; Genome; Human; Genetics
dc.subject; Genomics
dc.subject; Genotype
dc.subject; Greenland
dc.subject; Hair
dc.subject; History; Ancient
dc.subject; Humans
dc.subject; Inuits
dc.subject; Male
dc.subject; Phenotype
dc.subject; Phylogeny
dc.subject; Polymorphism; Single nucleotide
dc.subject; Sequence analysis; DNA
dc.subject; Siberia; Ethnology
dc.subject; REF 2014
dc.titleAncient human genome sequence of an extinct Palaeo-Eskimo
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository


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