Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity
dc.contributor.author | Pors, Klaus | * |
dc.contributor.author | Loadman, Paul | * |
dc.contributor.author | Shnyder, Steven | * |
dc.contributor.author | Sutherland, Mark | * |
dc.contributor.author | Sheldrake, Helen M. | * |
dc.contributor.author | Guino, M. | * |
dc.contributor.author | Kiakos, K. | * |
dc.contributor.author | Hartley, J.A. | * |
dc.contributor.author | Searcey, M. | * |
dc.contributor.author | Patterson, Laurence H. | * |
dc.date.accessioned | 2014-04-28T11:14:24Z | |
dc.date.available | 2014-04-28T11:14:24Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Pors K, Loadman PM, Shnyder SD et al (2011) Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity. Chemical Communications. 47(44): 12062-12064. | |
dc.identifier.uri | http://hdl.handle.net/10454/6138 | |
dc.description | No | |
dc.description.abstract | The identification of an agent that is selectively activated by a cytochrome P450 (CYP) has the potential for tissue specific dose intensification as a means of significantly improving its therapeutic value. Towards this goal, we disclose evidence for the pathway of activation of a duocarmycin analogue, ICT2700, which targets CYP1A1 for biological activity. | |
dc.language.iso | en | |
dc.subject | Alkylating agents | |
dc.subject | Animals | |
dc.subject | Biotransformation | |
dc.subject | CHO cells | |
dc.subject | Cricetinae | |
dc.subject | Cricetulus | |
dc.subject | Cytochrome P-450 CYP1A1 | |
dc.subject | Cytotoxins | |
dc.subject | Humans | |
dc.subject | Indoles | |
dc.subject | Molecular targeted therapy | |
dc.subject | Oxidation-reduction | |
dc.subject | REF 2014 | |
dc.title | Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity | |
dc.type | Article | |
dc.type.version | No full-text in the repository | |
dc.identifier.doi | https://doi.org/10.1039/c1cc15638a | |
dc.openaccess.status | closedAccess |