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dc.contributor.authorPedersen, M.*
dc.contributor.authorvon Stedingk, H.*
dc.contributor.authorBotsivali, M.*
dc.contributor.authorAgramunt, S.*
dc.contributor.authorAlexander, J.*
dc.contributor.authorBrunborg, G.*
dc.contributor.authorChatzi, L.*
dc.contributor.authorFleming, S.*
dc.contributor.authorFthenou, E.*
dc.contributor.authorGranum, B.*
dc.contributor.authorGutzkow, K.B.*
dc.contributor.authorHardie, L.J.*
dc.contributor.authorKnudsen, L.E.*
dc.contributor.authorKyrtopoulos, S.A.*
dc.contributor.authorMendez, M.A.*
dc.contributor.authorMerlo, D.F.*
dc.contributor.authorNielsen, J.K.*
dc.contributor.authorRydberg, P.*
dc.contributor.authorSegerback, D.*
dc.contributor.authorSunyer, J.*
dc.contributor.authorWright, J.*
dc.contributor.authorTornqvist, M.*
dc.contributor.authorKleinjans, J.C.*
dc.contributor.authorKogevinas, M.*
dc.contributor.authorNewGeneris, Consortium*
dc.date.accessioned2014-04-28T11:05:03Z
dc.date.available2014-04-28T11:05:03Z
dc.date.issued2012
dc.identifier.citationPedersen, M., von Stedingk, H., Botsivali, M., Agramunt, S., Alexander, J., Brunborg, G., Chatzi, L., Fleming, S., Fthenou, E., Granum, B., Gutzkow, K. B., Hardie, L. J., Knudsen, L. E., Kyrtopoulos, S. A., Mendez, M. A., Merlo, D. F., Nielsen, J. K., Rydberg, P., Segerback, D., Sunyer, J., Wright, J., Tornqvist, M., Kleinjans, J. C., Kogevinas, M., NewGeneris, Consortium (2012) Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris). Environmental Health Perspectives, 120 (12), 1739-45.
dc.identifier.urihttp://hdl.handle.net/10454/6129
dc.description.abstractBACKGROUND: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. OBJECTIVES: We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother-child study. METHODS: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires. RESULTS: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. CONCLUSIONS: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure in utero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1289/ehp.1205327
dc.subjectAcrylamide; Blood
dc.subjectAdult
dc.subjectBirth weight
dc.subjectChromatography; Liquid
dc.subjectCohort studies
dc.subjectDiet
dc.subjectEnvironmental exposure
dc.subjectEnvironmental monitoring
dc.subjectEnvironmental pollutants
dc.subjectEpoxy compounds
dc.subjectEurope; Epidemiology
dc.subjectFemale
dc.subjectFetal Blood; Chemistry
dc.subjectHead; Anatomy & histology
dc.subjectHemoglobins; Metabolism
dc.subjectHumans
dc.subjectInfant; Low birth weight
dc.subjectNewborn
dc.subjectMass spectrometry
dc.subjectMaternal exposure
dc.subjectPregnancy
dc.subjectPrenatal exposure delayed effects
dc.subjectProspective studies
dc.subjectQuestionnaires
dc.subjectRegression analysis
dc.subjectREF 2014
dc.titleBirth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)
dc.typeArticle


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