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    Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)

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    Publication date
    2012
    Author
    Pedersen, M.
    von Stedingk, H.
    Botsivali, M.
    Agramunt, S.
    Alexander, J.
    Brunborg, G.
    Chatzi, L.
    Fleming, S.
    Fthenou, E.
    Granum, B.
    Gutzkow, K.B.
    Hardie, L.J.
    Knudsen, L.E.
    Kyrtopoulos, S.A.
    Mendez, M.A.
    Merlo, D.F.
    Nielsen, J.K.
    Rydberg, P.
    Segerback, D.
    Sunyer, J.
    Wright, J.
    Tornqvist, M.
    Kleinjans, J.C.
    Kogevinas, M.
    NewGeneris, Consortium
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    Keyword
    Acrylamide; Blood
    Adult
    Birth weight
    Chromatography; Liquid
    Cohort studies
    Diet
    Environmental exposure
    Environmental monitoring
    Environmental pollutants
    Epoxy compounds
    Europe; Epidemiology
    Female
    Fetal Blood; Chemistry
    Head; Anatomy & histology
    Hemoglobins; Metabolism
    Humans
    Infant; Low birth weight
    Newborn
    Mass spectrometry
    Maternal exposure
    Pregnancy
    Prenatal exposure delayed effects
    Prospective studies
    Questionnaires
    Regression analysis
    REF 2014
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    Abstract
    BACKGROUND: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. OBJECTIVES: We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother-child study. METHODS: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires. RESULTS: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. CONCLUSIONS: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure in utero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.
    URI
    http://hdl.handle.net/10454/6129
    Citation
    Pedersen, M., von Stedingk, H., Botsivali, M., Agramunt, S., Alexander, J., Brunborg, G., Chatzi, L., Fleming, S., Fthenou, E., Granum, B., Gutzkow, K. B., Hardie, L. J., Knudsen, L. E., Kyrtopoulos, S. A., Mendez, M. A., Merlo, D. F., Nielsen, J. K., Rydberg, P., Segerback, D., Sunyer, J., Wright, J., Tornqvist, M., Kleinjans, J. C., Kogevinas, M., NewGeneris, Consortium (2012) Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris). Environmental Health Perspectives, 120 (12), 1739-45.
    Link to publisher’s version
    http://dx.doi.org/10.1289/ehp.1205327
    Type
    Article
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    Health Studies Publications

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