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dc.contributor.authorNasim, Md. Talat
dc.contributor.authorOgo, T.
dc.contributor.authorAhmed, Mohammed I.
dc.contributor.authorRandall, R.
dc.contributor.authorChowdhury, H.M.
dc.contributor.authorSnape, K.M.
dc.contributor.authorBradshaw, T.Y.
dc.contributor.authorSouthgate, L.
dc.contributor.authorLee, G.J.
dc.contributor.authorJackson, I.
dc.contributor.authorLord, G.M.
dc.contributor.authorGibbs, J.S.
dc.contributor.authorWilkins, M.R.
dc.contributor.authorOhta-Ogo, K.
dc.contributor.authorNakamura, K.
dc.contributor.authorGirerd, B.
dc.contributor.authorCoulet, F.
dc.contributor.authorSoubrier, F.
dc.contributor.authorHumbert, M.
dc.contributor.authorMorrell, N.W.
dc.contributor.authorTrembath, R.C.
dc.contributor.authorMachado, R.D.
dc.date.accessioned2014-04-28T11:05:00Z
dc.date.available2014-04-28T11:05:00Z
dc.date.issued2011
dc.identifier.citationNasim MT, Ogo T and Ahmed M et al (2011) Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension. Human Mutation. 32(12): 1385-1389.
dc.identifier.urihttp://hdl.handle.net/10454/6114
dc.description.abstractHeterozygous germline mutations of BMPR2 contribute to familial clustering of pulmonary arterial hypertension (PAH). To further explore the genetic basis of PAH in isolated cases, we undertook a candidate gene analysis to identify potentially deleterious variation. Members of the bone morphogenetic protein (BMP) pathway, namely SMAD1, SMAD4, SMAD5, and SMAD9, were screened by direct sequencing for gene defects. Four variants were identified in SMADs 1, 4, and 9 among a cohort of 324 PAH cases, each not detected in a substantial control population. Of three amino acid substitutions identified, two demonstrated reduced signaling activity in vitro. A putative splice site mutation in SMAD4 resulted in moderate transcript loss due to compromised splicing efficiency. These results demonstrate the role of BMPR2 mutation in the pathogenesis of PAH and indicate that variation within the SMAD family represents an infrequent cause of the disease.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1002/humu.21605
dc.subjectBone morphogenetic protein receptors; Type II; Genetics; Cohort studies; Female; Gene expression regulation; Humans; Hypertension; Pulmonary; Male; Sequence analysis; DNA; Signal transduction; Smad1 protein; Smad8 protein; Transcriptional regulation; REF 2014
dc.titleMolecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension
dc.typeArticle
refterms.dateFOA2018-07-19T10:21:46Z


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