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    Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle

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    Publication date
    2010
    Author
    Mardaryev, Andrei N.
    Ahmed, Mohammed I.
    Vlahov, Nikola V.
    Fessing, Michael Y.
    Gill, Jason H.
    Sharov, A.A.
    Botchkareva, Natalia V.
    Keyword
    Hair follicles; Micro-RNAs; miRNAs; Gene expression and silencing; Hair cycle
    ; REF 2014
    
    Metadata
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    Abstract
    The hair follicle is a cyclic biological system that progresses through stages of growth, regression, and quiescence, which involves dynamic changes in a program of gene regulation. Micro-RNAs (miRNAs) are critically important for the control of gene expression and silencing. Here, we show that global miRNA expression in the skin markedly changes during distinct stages of the hair cycle in mice. Furthermore, we show that expression of miR-31 markedly increases during anagen and decreases during catagen and telogen. Administration of antisense miR-31 inhibitor into mouse skin during the early- and midanagen phases of the hair cycle results in accelerated anagen development, and altered differentiation of hair matrix keratinocytes and hair shaft formation. Microarray, qRT-PCR and Western blot analyses revealed that miR-31 negatively regulates expression of Fgf10, the components of Wnt and BMP signaling pathways Sclerostin and BAMBI, and Dlx3 transcription factor, as well as selected keratin genes, both in vitro and in vivo. Using luciferase reporter assay, we show that Krt16, Krt17, Dlx3, and Fgf10 serve as direct miR-31 targets. Thus, by targeting a number of growth regulatory molecules and cytoskeletal proteins, miR-31 is involved in establishing an optimal balance of gene expression in the hair follicle required for its proper growth and hair fiber formation.
    URI
    http://hdl.handle.net/10454/6078
    Citation
    Mardaryev AN, Ahmed MI, Vlahov NV et al (2010) Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB Journal. 24(10): 3869-3881.
    Link to publisher’s version
    http://dx.doi.org/10.1096/fj.10-160663
    Type
    Article
    Collections
    Life Sciences Publications

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