Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
Publication date
2010Author
Kickstein, E.Krauss, S.
Thornhill, P.
Rutschow, D.
Zeller, R.
Sharkey, J.
Williamson, Ritchie
Fuchs, M.
Kohler, A.
Glossmann, H.
Schneider, R.
Sutherland, C.
Schweiger, S.
Keyword
Adenylate Kinase; Metabolism; Alzheimer Disease; Pathology; Physiopathology
; Animals
; Cells; Cultured
; Enzyme Inhibitors; Pharmacology
; Epitopes
; HeLa cells
; Humans
; Hypoglycemic agents
; Metformin
; Mice
; Transgenic
; Multiprotein complexes
; Neurofibrillary Tangles
; Neurons; Cytology
; Okadaic acid
; Phosphorylation
; Protein Phosphatase 2
; Proteins
; Signal Transduction; Drug effects
; TOR Serine-Threonine Kinases
; Tau Proteins
; REF 2014