Show simple item record

dc.contributor.authorGray, E.*
dc.contributor.authorThomas, T. L.*
dc.contributor.authorBetmouni, S.*
dc.contributor.authorScolding, N.*
dc.contributor.authorLove, S.*
dc.date.accessioned2014-04-28T10:41:15Z
dc.date.available2014-04-28T10:41:15Z
dc.date.issued2008
dc.identifier.citationGray, E., Thomas, T. L., Betmouni, S., Scolding, N., Love, S. (2008) Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis. Brain Pathology, 18 (1), 86-95.
dc.identifier.urihttp://hdl.handle.net/10454/6000
dc.description.abstractRecent studies have revealed extensive cortical demyelination in patients with progressive multiple sclerosis (MS). Demyelination in gray matter lesions is associated with activation of microglia. Macrophages and microglia are known to express myeloperoxidase (MPO) and generate reactive oxygen species during myelin phagocytosis in the white matter. In the present study we examined the extent of microglial activation in the cerebral cortex and the relationship of microglial activation and MPO activity to cortical demyelination. Twenty-one cases of neuropathologically confirmed multiple sclerosis, with 34 cortical lesions, were used to assess microglial activation. HLA-DR immunolabeling of activated microglia was significantly higher in demyelinated MS cortex than control cortex and, within the MS cohort, was significantly greater within cortical lesions than in matched non-demyelinated areas of cortex. In homogenates of MS cortex, cortical demyelination was associated with significantly elevated MPO activity. Immunohistochemistry revealed MPO in CD68-positive microglia within cortical plaques, particularly toward the edge of the plaques, but not in microglia in adjacent non-demyelinated cortex. Cortical demyelination in MS is associated with increased activity of MPO, which is expressed by a CD68-positive subset of activated microglia, suggesting that microglial production of reactive oxygen species is likely to be involved in cortical demyelination.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1111/j.1750-3639.2007.00110.x
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAntigens; CD/immunology; Metabolism
dc.subjectAntigens; Differentiation; Myelomonocytic; Immunology
dc.subjectBiological markers; Analysis
dc.subjectCerebral cortex; Enzymology; Pathology; Physiopathology
dc.subjectEncephalitis
dc.subjectEnzyme activation
dc.subjectFemale
dc.subjectGliosis
dc.subjectHLA-DR antigens
dc.subjectHumans
dc.subjectMale
dc.subjectMicroglia
dc.subjectMiddle aged
dc.subjectMultiple Sclerosis
dc.subjectMyelin sheath
dc.subjectNerve fibers; Myelinated
dc.subjectOxidative stress
dc.subjectPeroxidase
dc.subjectReactive oxygen species
dc.subjectUp-regulation
dc.subjectWallerian degeneration
dc.subjectREF 2014
dc.titleElevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis
dc.typeArticle


This item appears in the following Collection(s)

Show simple item record