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    p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis

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    Publication date
    2011
    Author
    Fessing, Michael Y.
    Mardaryev, Andrei N.
    Gdula, Michal R.
    Sharov, A.A.
    Sharova, T.Y.
    Rapisarda, Valentina
    Gordon, K.B.
    Smorodchenko, A.D.
    Poterlowicz, Krzysztof
    Ferone, G.
    Kohwi, Y.
    Missero, C.
    Kohwi-Shigematsu, T.
    Botchkarev, Vladimir A.
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    Keyword
    Animals
    ; Cell differentiation
    ; Chromatin; Metabolism
    ; Chromatin assembly and disassembly; Genetics
    ; Epidermis; Cytology; Embryology
    ; Gene expression regulation; Developmental
    ; Genome
    ; In situ hybridization; Fluorescence
    ; Matrix attachment region binding proteins
    ; Mice
    ; Inbred C57BL
    ; Phosphoproteins
    ; Trans-activators
    ; REF 2014
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    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    During development, multipotent progenitor cells establish tissue-specific programs of gene expression. In this paper, we show that p63 transcription factor, a master regulator of epidermal morphogenesis, executes its function in part by directly regulating expression of the genome organizer Satb1 in progenitor cells. p63 binds to a proximal regulatory region of the Satb1 gene, and p63 ablation results in marked reduction in the Satb1 expression levels in the epidermis. Satb1(-/-) mice show impaired epidermal morphology. In Satb1-null epidermis, chromatin architecture of the epidermal differentiation complex locus containing genes associated with epidermal differentiation is altered primarily at its central domain, where Satb1 binding was confirmed by chromatin immunoprecipitation-on-chip analysis. Furthermore, genes within this domain fail to be properly activated upon terminal differentiation. Satb1 expression in p63(+/-) skin explants treated with p63 small interfering ribonucleic acid partially restored the epidermal phenotype of p63-deficient mice. These data provide a novel mechanism by which Satb1, a direct downstream target of p63, contributes in epidermal morphogenesis via establishing tissue-specific chromatin organization and gene expression in epidermal progenitor cells.
    URI
    http://hdl.handle.net/10454/5968
    Version
    No full-text in the repository
    Citation
    Fessing MY, Mardaryev AN, Gdula MR et al. (2011) p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. Journal of Cell Biology. 194(6): 825-839.
    Link to publisher’s version
    http://dx.doi.org/10.1083/jcb.201101148
    Type
    Article
    Collections
    Life Sciences Publications

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