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    Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons

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    Publication date
    2009
    Author
    Corrêa, Sonia A.L.
    Muller, Jurgen
    Collingridge, G.L.
    Marrion, N.V.
    Keyword
    Amino acid motifs
    ; Animals
    ; Cells
    ; Clathrin
    ; Endocytosis
    ; Hippocampus
    ; Neurons
    ; Point mutation
    ; Protein subunits
    ; Protein transport
    ; Rats
    ; Small-conductance calcium-activated potassium channels
    ; REF 2014
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    Peer-Reviewed
    Yes
    
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    Abstract
    Trafficking motifs present in the intracellular regions of ion channels affect their subcellular location within neurons. The mechanisms that control trafficking to dendrites of central neurons have been identified, but it is not fully understood how channels are localized to the soma. We have now identified a motif within the calcium-activated potassium channel K(Ca)2.1 (SK1) that results in somatic localization. Transfection of hippocampal neurons with K(Ca)2.1 subunits causes expression of functional channels in only the soma and proximal processes. By contrast, expressed K(Ca)2.3 subunits are located throughout the processes of transfected neurons. Point mutation of K(Ca)2.1 within this novel motif to mimic a sequence present in the C-terminus of K(Ca)2.3 causes expression of K(Ca)2.1 subunits throughout the processes. We also demonstrate that blocking of clathrin-mediated endocytosis causes K(Ca)2.1 subunit expression to mimic that of the mutated subunit. The role of this novel motif is therefore not to directly target trafficking of the channel to subcellular compartments, but to regulate channel location by subjecting it to rapid clathrin-mediated endocytosis.
    URI
    http://hdl.handle.net/10454/5941
    Version
    No full-text in the repository
    Citation
    Correa SA, Muller J, Collingridge GL and Marrion NV (2009) Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons. Journal of Cell Science. 122(Pt 22): 4186-4194.
    Link to publisher’s version
    http://dx.doi.org/10.1242/jcs.058420
    Type
    Article
    Collections
    Life Sciences Publications

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