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dc.contributor.authorChamberlain, S.E.*
dc.contributor.authorGonzàlez-Gonzàlez, I.M.*
dc.contributor.authorWilkinson, K.A.*
dc.contributor.authorKonopacki, F.A.*
dc.contributor.authorKantamneni, Sriharsha*
dc.contributor.authorHenley, J.M.*
dc.contributor.authorMellor, J.R.*
dc.date.accessioned2014-04-25T12:33:00Z
dc.date.available2014-04-25T12:33:00Z
dc.date.issued2012
dc.identifier.citationChamberlain SE, Gonzalez-Gonzalez IM, Wilkinson KA et al (2012) SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity. Nature Neuroscience. 15(6): 845-852.
dc.identifier.urihttp://hdl.handle.net/10454/5911
dc.descriptionNo
dc.description.abstractPhosphorylation or SUMOylation of the kainate receptor (KAR) subunit GluK2 have both individually been shown to regulate KAR surface expression. However, it is unknown whether phosphorylation and SUMOylation of GluK2 are important for activity-dependent KAR synaptic plasticity. We found that protein kinase C-mediated phosphorylation of GluK2 at serine 868 promotes GluK2 SUMOylation at lysine 886 and that both of these events are necessary for the internalization of GluK2-containing KARs that occurs during long-term depression of KAR-mediated synaptic transmission at rat hippocampal mossy fiber synapses. Conversely, phosphorylation of GluK2 at serine 868 in the absence of SUMOylation led to an increase in KAR surface expression by facilitating receptor recycling between endosomal compartments and the plasma membrane. Our results suggest a role for the dynamic control of synaptic SUMOylation in the regulation of KAR synaptic transmission and plasticity.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1038/nn.3089
dc.subjectAnimals
dc.subject; Excitatory postsynaptic potentials
dc.subject; HEK293 cells
dc.subject; Humans
dc.subject; Mossy fibers
dc.subject; Neuronal plasticity
dc.subject; Organ culture techniques
dc.subject; Patch-clamp techniques
dc.subject; Phosphorylation
dc.subject; Protein transport
dc.subject; Rats
dc.subject; Wistar
dc.subject; Receptors; Kainic acid
dc.subject; Sumoylation
dc.subject; Synaptic transmission
dc.subject; Transfection
dc.subject; REF 2014
dc.titleSUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository


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