The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo
Publication date
2011Author
Burns, C.J.Fantino, E.
Powell, A.K.
Shnyder, Steven D.
Cooper, Patricia A.
Nelson, S.
Christophi, C.
Malcontenti-Wilson, C.
Dubljevic, V.
Harte, M.F.
Joffe, M.
Phillips, I.D.
Segal, D.
Wilks, A.F.
Smith, G.D.
Keyword
Angiogenesis inhibitors; Pharmacology;Animals;
Antineoplastic agents;
Cell line; Tumor;
Cell proliferation; Drug effects;
Colonic neoplasms; Blood supply; Drug therapy; Pathology;
Dose-response relationship;
Drug screening assays; Antitumor;
Human umbilical vein endothelial cells;
Humans;
Liver neoplasms; Secondary;
Male;
Mice;
Nude;
Neovascularization;
Pyridines;
Pyrimidines;
Time factors;
Tubulin modulators;
Vascular endothelial growth factor A/antagonists & inhibitors;
Xenograft model antitumor assays;
REF 2014