• Secondary metabolites from Xylariaceous fungi. The isolation and structure elucidation of secondary metabolites from Xylariaceous fungi by chemical and spectroscopic methods.

      Maitland, Derek J.; Alhaidari, Rwaida A.A. (University of BradfordDivision of Chemical and Forensic Sciences, 2013-11-21)
      This thesis describes the isolation and structure elucidation of secondary metabolites formed in static culture from a number of endophytic Xylariaceous fungi. Four Xylaria endophytes isolated from a palm tree in Thailand were surface cultured on an aqueous malt extract-glucose medium. They all produced cytochalasin D, coriloxin, (S)-mellein and (3R,4R)-4-hydroxymellein as the main secondary metabolites suggesting that the four endophytes could be the same species. The endophytic fungus A116 produced cytochalasin D as the main secondary metabolite. Another non-endophytic fungus B315, produced cytochalasin D, (R)-mellein, a mixture of two isomers of 4-hydroxymellein and phloroglucinol. X.62, an endophytic fungus, produced 19,20-epoxycytochalasin C from the mycelium as the main secondary metabolite. The fungus Engleromyces sinensis produced engleromycin acetate as the main secondary metabolite. Fungus X. polymorpha produced (3E)-4-(3¿-acetyl-2¿,6¿-dihydroxy-5¿-methylphenyl)-2-methoxybut-3-enoic acid.