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dc.contributor.advisorMaitland, Derek J.
dc.contributor.authorAlhaidari, Rwaida A.A.*
dc.date.accessioned2013-11-21T19:01:43Z
dc.date.available2013-11-21T19:01:43Z
dc.date.issued2013-11-21
dc.identifier.urihttp://hdl.handle.net/10454/5705
dc.description.abstractThis thesis describes the isolation and structure elucidation of secondary metabolites formed in static culture from a number of endophytic Xylariaceous fungi. Four Xylaria endophytes isolated from a palm tree in Thailand were surface cultured on an aqueous malt extract-glucose medium. They all produced cytochalasin D, coriloxin, (S)-mellein and (3R,4R)-4-hydroxymellein as the main secondary metabolites suggesting that the four endophytes could be the same species. The endophytic fungus A116 produced cytochalasin D as the main secondary metabolite. Another non-endophytic fungus B315, produced cytochalasin D, (R)-mellein, a mixture of two isomers of 4-hydroxymellein and phloroglucinol. X.62, an endophytic fungus, produced 19,20-epoxycytochalasin C from the mycelium as the main secondary metabolite. The fungus Engleromyces sinensis produced engleromycin acetate as the main secondary metabolite. Fungus X. polymorpha produced (3E)-4-(3¿-acetyl-2¿,6¿-dihydroxy-5¿-methylphenyl)-2-methoxybut-3-enoic acid.en_US
dc.description.sponsorshipMinistry of Higher Education; Kingdom of Saudi Arabia.en_US
dc.language.isoenen_US
dc.rights<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.eng
dc.subjectEndophytesen_US
dc.subjectXylariaen_US
dc.subjectFungien_US
dc.subjectSecondary metabolitesen_US
dc.subjectNMRen_US
dc.subjectStructure elucidationen_US
dc.subjectXylariaceous fungien_US
dc.titleSecondary metabolites from Xylariaceous fungi. The isolation and structure elucidation of secondary metabolites from Xylariaceous fungi by chemical and spectroscopic methods.en_US
dc.type.qualificationleveldoctoralen_US
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentDivision of Chemical and Forensic Sciencesen_US
dc.typeThesiseng
dc.type.qualificationnamePhDen_US
dc.date.awarded2012
refterms.dateFOA2018-07-19T12:25:06Z


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