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    Development of a solvent free continuous co-crystallisation technique for carbamazepine ¿ saccharin.

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    O.D. JOSHI.pdf (5.264Mb)
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    Publication date
    2013-11-21
    Author
    Joshi, Onkar D.
    Supervisor
    Paradkar, Anant R.
    Kelly, Adrian L.
    Keyword
    Co-crystal
    Solvent free
    Continuous
    Carbamazepine
    Drug preparation
    Rights
    Creative Commons License
    The University of Bradford theses are licenced under a Creative Commons Licence.
    Institution
    University of Bradford
    Department
    School of Life Sciences
    Awarded
    2012
    
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    Abstract
    Co-crystals are emerging as a potential area in the field of crystal designing as it improves material¿s physicochemical properties. Many groups are working on the development of newer techniques for the preparation of co-crystals, which can be scalable and contribute to the green agenda. Being continuous and scalable technique, our own developed twin screw extrusion mediated solvent free continuous co-crystallisation (SFCC) technique has been used for the preparation of carbamazepine: saccharin co-crystal. Carbamazepine has been used as a model drug since it shows challenges such as low solubility (BCS class II), polymorphism and thermolabile nature whilst, saccharin was used as a co-former. Effect of extrusion processing parameters such as shear, temperature and screw speed on cocrystallisation has been studied. In addition to this, effect of particle size of co-crystal components, use of hydrated form of carbamazepine, addition of solvent and application of reverse elements on the purity of co-crystal was understood. Use of carbamazepine dihydrate as a starting component yields pure co-crystals. The addition of small amount of polar solvent in anhydrous carbamazepine also yields pure co-crystals whereas particle size did not show any significant effect. Result showed that selection of processing temperature near to eutectic, moderate shear and increase in residence time of component mixture in mixing zone was mainly responsible for co-crystallisation. The extrudates were mainly characterised by XRPD, DSC and in-vitro dissolution tests. Pure co-crystals prepared by addition of highly Development of a solvent free continuous co-crystallisation technique for carbamazepine-saccharin ii polar solvent have been showed drug release identical to that of pure co-crystals prepared by solvent crystallisation.
    URI
    http://hdl.handle.net/10454/5697
    Type
    Thesis
    Qualification name
    MPhil
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    Theses

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