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dc.contributor.authorClare, L.*
dc.contributor.authorBayer, A.*
dc.contributor.authorBurns, A.*
dc.contributor.authorCorbett, A.*
dc.contributor.authorJones, R.*
dc.contributor.authorKnapp, M.*
dc.contributor.authorKopelman, M.*
dc.contributor.authorKudlicka, A.*
dc.contributor.authorLeroi, I.*
dc.contributor.authorOyebode, Jan R.*
dc.contributor.authorPool, J.*
dc.contributor.authorWoods, B.*
dc.contributor.authorWhitaker, R.*
dc.date.accessioned2013-06-13T16:44:00Z
dc.date.available2013-06-13T16:44:00Z
dc.date.issued2013-05-27
dc.identifier.citationClare L, Bayer A, Burns A et al (2013) Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials. 14(1): 152 (15p.)en_US
dc.identifier.urihttp://hdl.handle.net/10454/5615
dc.descriptionyesen_US
dc.description.abstractBackground: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer's disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers. Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined. Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion. Trial registration: Current Controlled Trials ISRCTN21027481en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://www.trialsjournal.com/content/14/1/152en_US
dc.rights© 2013 Clare, L. et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectAlzheimer's diseaseen_US
dc.subject; Vascular dementiaen_US
dc.subject; Mixed dementiaen_US
dc.subject; Re-ablementen_US
dc.subject; Quality of lifeen_US
dc.subject; Cost-effectivenessen_US
dc.subject; Cognitive Rehabilitation (CR)en_US
dc.titleGoal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT).en_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionpublished version paperen_US
refterms.dateFOA2018-07-19T11:27:08Z


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