Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT).
dc.contributor.author | Clare, L. | * |
dc.contributor.author | Bayer, A. | * |
dc.contributor.author | Burns, A. | * |
dc.contributor.author | Corbett, A. | * |
dc.contributor.author | Jones, R. | * |
dc.contributor.author | Knapp, M. | * |
dc.contributor.author | Kopelman, M. | * |
dc.contributor.author | Kudlicka, A. | * |
dc.contributor.author | Leroi, I. | * |
dc.contributor.author | Oyebode, Jan R. | * |
dc.contributor.author | Pool, J. | * |
dc.contributor.author | Woods, B. | * |
dc.contributor.author | Whitaker, R. | * |
dc.date.accessioned | 2013-06-13T16:44:00Z | |
dc.date.available | 2013-06-13T16:44:00Z | |
dc.date.issued | 2013-05-27 | |
dc.identifier.citation | Clare L, Bayer A, Burns A et al (2013) Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials. 14(1): 152 (15p.) | en_US |
dc.identifier.uri | http://hdl.handle.net/10454/5615 | |
dc.description | yes | en_US |
dc.description.abstract | Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer's disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers. Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined. Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion. Trial registration: Current Controlled Trials ISRCTN21027481 | en_US |
dc.language.iso | en | en_US |
dc.relation.isreferencedby | http://www.trialsjournal.com/content/14/1/152 | en_US |
dc.rights | © 2013 Clare, L. et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | ; Vascular dementia | en_US |
dc.subject | ; Mixed dementia | en_US |
dc.subject | ; Re-ablement | en_US |
dc.subject | ; Quality of life | en_US |
dc.subject | ; Cost-effectiveness | en_US |
dc.subject | ; Cognitive Rehabilitation (CR) | en_US |
dc.title | Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). | en_US |
dc.status.refereed | yes | en_US |
dc.type | Article | en_US |
dc.type.version | published version paper | en_US |
refterms.dateFOA | 2018-07-19T11:27:08Z |