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    Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT).

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    clare et al 2013 GREAT protocol in Trials-1.pdf (1.211Mb)
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    Publication date
    2013-05-27
    Author
    Clare, L.
    Bayer, A.
    Burns, A.
    Corbett, A.
    Jones, R.
    Knapp, M.
    Kopelman, M.D.
    Kudlicka, A.
    Leroi, I.
    Oyebode, Jan R.
    Pool, J.
    Woods, B.
    Whitaker, R.
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    Keyword
    Alzheimer's disease
    ; Vascular dementia
    ; Mixed dementia
    ; Re-ablement
    ; Quality of life
    ; Cost-effectiveness
    ; Cognitive Rehabilitation (CR)
    Rights
    © 2013 Clare, L. et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Peer-Reviewed
    yes
    
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    Abstract
    Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer's disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers. Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined. Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion. Trial registration: Current Controlled Trials ISRCTN21027481
    URI
    http://hdl.handle.net/10454/5615
    Version
    published version paper
    Citation
    Clare L, Bayer A, Burns A et al (2013) Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT). Trials. 14(1): 152 (15p.)
    Link to publisher’s version
    http://www.trialsjournal.com/content/14/1/152
    Type
    Article
    Collections
    Health Studies Publications

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