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dc.contributor.authorGrant, Colin A.*
dc.contributor.authorTwigg, Peter C.*
dc.contributor.authorTobin, Desmond J.*
dc.date.accessioned2012-12-06T10:59:21Z
dc.date.available2012-12-06T10:59:21Z
dc.date.issued06/07/2012
dc.identifier.citationGrant, C. A., Twigg, P. C., and Tobin, D. J. (2012). Static and dynamic nanomechanical properties of human skin tissue using atomic force microscopy: Effect of scarring in the upper dermis. Acta Biomaterialia. Vol. 8, No. 11, pp. 4123-4129.en_US
dc.identifier.urihttp://hdl.handle.net/10454/5495
dc.descriptionnoen_US
dc.description.abstractFollowing traumatic injury, skin has the capacity to repair itself through a complex cascade of biochemical change. The dermis, which contains a load-bearing collagenous network structure, is remodelled over a long period of time, affecting its mechanical behaviour. This study examines the nanomechanical and viscoelastic properties of the upper dermis from human skin that includes both healthy intact and scarred tissue. Extensive nanoindentation analysis shows that the dermal scar tissue exhibits stiffer behaviour than the healthy intact skin. The scar skin also shows weaker viscoelastic creep and capability to dissipate energy at physiologically relevant frequencies than the adjacent intact skin. These results are discussed in conjunction with a visual change in the orientation of collagenous fibrils in the scarred dermis compared with normal dermis, as shown by atomic force microscopy imaging.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://www.sciencedirect.com/science/article/pii/S1742706112002991en_US
dc.subjectAtomic force microscopy (AFM)en_US
dc.subjectSkinen_US
dc.subjectScar tissueen_US
dc.subjectViscoelasticityen_US
dc.subjectCreep indentationen_US
dc.subjectWound healingen_US
dc.subjectDermisen_US
dc.titleStatic and dynamic nanomechanical properties of human skin tissue using atomic force microscopy: Effect of scarring in the upper dermis.en_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionpublished version paperen_US


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