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dc.contributor.authorAhmat, Norhayati
dc.contributor.authorUgail, Hassan
dc.contributor.authorGonzalez Castro, Gabriela
dc.date.accessioned2012-05-01T15:58:38Z
dc.date.available2012-05-01T15:58:38Z
dc.date.issued2012-01
dc.identifier.citationAhmat, N., Ugail, H. and Gonzalez Castro, G. (2012). Modelling the Mechanical Behaviour of a Pharmaceutical Tablet Using PDEs. In: Gunther, M., Bartel, A., Brunk, M., Schops, S. and Striebel, M. (Eds.). Progress in Industrial Mathematics at ECMI 2010. Springer. pp. 505-512.en_US
dc.identifier.urihttp://hdl.handle.net/10454/5428
dc.descriptionyesen_US
dc.description.abstractDetailed design of pharmaceutical tablets is essential nowadays in order to produce robust tablets with tailor-made properties. Compressibility and compactibility are the main compaction properties involved in the design and development of solid dosage forms. The data obtained from measured forces and displacements of the punch are normally analysed using the Heckel model to assess the mechanical behaviour of pharmaceutical powders. In this paper, we present a technique for shape modelling of pharmaceutical tablets based on the PDE method. We extended the formulation of the PDE method to a higher dimensional space in order to generate a solid tablet and a cuboid mesh is created to represent the tablet¿s components. We also modelled the displacement components of a compressed PDE- based representation of a tablet by utilising the solution of the axisymmetric boundary value problem for a finite cylinder subject to a uniform axial load. The experimental data and the results obtained from the developed model are shown in Heckel plots and a good agreement is found between both.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://www.springer.com/mathematics/applications/book/978-3-642-25099-6en_US
dc.rights© 2012 Springer. Reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectPDE-based surface representationen_US
dc.subjectPharmaceutical tabletsen_US
dc.subjectSolid dosage formsen_US
dc.subjectCompressibilityen_US
dc.subjectCompactibilityen_US
dc.subjectShape modellingen_US
dc.titleModelling the Mechanical Behaviour of a Pharmaceutical Tablet Using PDEs.en_US
dc.status.refereedyesen_US
dc.typeBook chapteren_US
dc.type.versionAccepted Manuscripten_US
dc.description.publicnotesAvailable in full text since 5th Feb 2013 following the publisher's embargo period.en
refterms.dateFOA2018-07-19T10:53:50Z


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