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dc.contributor.authorNicolaou, Anna
dc.contributor.authorMassey, Karen A.
dc.date.accessioned2011-11-21T16:30:43Z
dc.date.available2011-11-21T16:30:43Z
dc.date.issued2011
dc.identifier.citationMassey, K.A. and Nicolaou, A. (2011). Lipidomics of polyunsaturated fatty acid-derived oxygenated metabolites. Biochemical Society Transactions. Vol. 39, No. 5. pp. 1240-1249.en_US
dc.identifier.urihttp://hdl.handle.net/10454/5230
dc.descriptionNoen_US
dc.description.abstractNutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, as well as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://www.biochemsoctrans.org/bst/039/bst0391240.htmen_US
dc.subjectLipidomicsen_US
dc.subjectFatty Acidsen_US
dc.subjectMass Spectrometryen_US
dc.subjectPolyunsaturated Fatty Acidsen_US
dc.subjectPUFAen_US
dc.subjectCytochrome P450en_US
dc.subjectEicosanoiden_US
dc.subjectLOXen_US
dc.subjectCOXen_US
dc.subjectCyclo-Oxygenaseen_US
dc.subjectLipoxygenaseen_US
dc.titleLipidomics of polyunsaturated fatty acid-derived oxygenated metabolitesen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US


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