Lipidomics of polyunsaturated fatty acid-derived oxygenated metabolites
| dc.contributor.author | Nicolaou, Anna | * |
| dc.contributor.author | Massey, Karen A. | * |
| dc.date.accessioned | 2011-11-21T16:30:43Z | |
| dc.date.available | 2011-11-21T16:30:43Z | |
| dc.date.issued | 2011 | |
| dc.identifier.citation | Massey, K.A. and Nicolaou, A. (2011). Lipidomics of polyunsaturated fatty acid-derived oxygenated metabolites. Biochemical Society Transactions. Vol. 39, No. 5. pp. 1240-1249. | |
| dc.identifier.uri | http://hdl.handle.net/10454/5230 | |
| dc.description | No | |
| dc.description.abstract | Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, as well as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators. | |
| dc.language.iso | en | |
| dc.subject | Lipidomics | |
| dc.subject | Fatty Acids | |
| dc.subject | Mass Spectrometry | |
| dc.subject | Polyunsaturated Fatty Acids | |
| dc.subject | PUFA | |
| dc.subject | Cytochrome P450 | |
| dc.subject | Eicosanoid | |
| dc.subject | LOX | |
| dc.subject | COX | |
| dc.subject | Cyclo-Oxygenase | |
| dc.subject | Lipoxygenase | |
| dc.title | Lipidomics of polyunsaturated fatty acid-derived oxygenated metabolites | |
| dc.status.refereed | Yes | |
| dc.type | Article | |
| dc.type.version | No full-text in the repository | |
| dc.identifier.doi | https://doi.org/10.1042/BST0391240 | |
| dc.openaccess.status | closedAccess |