Lipidomics of polyunsaturated fatty acid-derived oxygenated metabolites
Publication date
2011Keyword
LipidomicsFatty Acids
Mass Spectrometry
Polyunsaturated Fatty Acids
PUFA
Cytochrome P450
Eicosanoid
LOX
COX
Cyclo-Oxygenase
Lipoxygenase
Peer-Reviewed
YesOpen Access status
closedAccess
Metadata
Show full item recordAbstract
Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, as well as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators.Version
No full-text in the repositoryCitation
Massey, K.A. and Nicolaou, A. (2011). Lipidomics of polyunsaturated fatty acid-derived oxygenated metabolites. Biochemical Society Transactions. Vol. 39, No. 5. pp. 1240-1249.Link to Version of Record
https://doi.org/10.1042/BST0391240Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1042/BST0391240