Show simple item record

dc.contributor.authorPilkington, S.M.*
dc.contributor.authorRhodes, L.E.*
dc.contributor.authorNicolaou, Anna*
dc.date.accessioned2011-11-21T15:59:37Z
dc.date.available2011-11-21T15:59:37Z
dc.date.issued2011
dc.identifier.citationNicolaou, A., Pilkington, S.M. and Rhodes, L.E. (2011). Ultraviolet-radiation induced skin inflammation: dissecting the role of bioactive lipids. Chemistry and Physics of Lipids. Vol. 164, No. 6. pp. 535-43.en_US
dc.identifier.urihttp://hdl.handle.net/10454/5228
dc.descriptionNoen_US
dc.description.abstractAcute exposure of human skin to the ultraviolet radiation (UVR) in sunlight results in the sunburn response. This is mediated in part by pro-inflammatory eicosanoids and other bioactive lipids, which are in turn produced via mechanisms including UVR-induction of oxidative stress, cell signalling and gene expression. Sunburn is a self-limiting inflammation offering a convenient and accessible system for the study of human cutaneous lipid metabolism. Recent lipidomic applications have revealed that a wider diversity of eicosanoids may be involved in the sunburn response than previously appreciated. This article reviews the effects of UVR on cutaneous lipids and examines the contribution of bioactive lipid mediators in the development of sunburn. Since human skin is an active site of polyunsaturated fatty acid (PUFA) metabolism, and these macronutrients can influence the production of eicosanoids/bioactive lipids, as well as modulate cell signalling, gene expression and oxidative stress, the application of PUFA as potential photoprotective agents is also considered.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.chemphyslip.2011.04.005en_US
dc.subjectUVRen_US
dc.subjectPolyunsaturated Fatty Acidsen_US
dc.subjectEicosanoidsen_US
dc.subjectLipidomicsen_US
dc.subjectSunburnen_US
dc.subjectLipoxygenaseen_US
dc.subjectClooxygenaseen_US
dc.titleUltraviolet-radiation induced skin inflammation: dissecting the role of bioactive lipidsen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US


This item appears in the following Collection(s)

Show simple item record