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dc.contributor.authorAhmat, Norhayati*
dc.contributor.authorUgail, Hassan*
dc.contributor.authorGonzalez Castro, Gabriela*
dc.date.accessioned2011-07-23T16:51:16Z
dc.date.available2011-07-23T16:51:16Z
dc.date.issued2010
dc.identifier.citationAhmat N., Ugail H. and Gonzalez Castro G. (2011). Method of modelling the compaction behaviour of cylindrical pharmaceutical tablets. International Journal of Pharmaceutics. Vol. 405, Nos. 1-2, pp. 113-121.en_US
dc.identifier.urihttp://hdl.handle.net/10454/4976
dc.descriptionNoen_US
dc.description.abstractThe mechanisms involved for compaction of pharmaceutical powders have become a crucial step in the development cycle for robust tablet design with required properties. Compressibility of pharmaceutical materials is measured by a force-displacement relationship which is commonly analysed using a well known method, the Heckel model. This model requires the true density and compacted powder mass value to determine the powder mean yield pressure. In this paper, we present a technique for shape modelling of pharmaceutical tablets based on the use of partial differential equations (PDEs). This work also presents an extended formulation of the PDE method to a higher dimensional space by increasing the number of parameters responsible for describing the surface in order to generate a solid tablet. Furthermore, the volume and the surface area of the parametric cylindrical tablet have been estimated numerically. Finally, the solution of the axisymmetric boundary value problem for a finite cylinder subject to a uniform axial load has been utilised in order to model the displacement components of a compressed PDE-based representation of a tablet. The Heckel plot obtained from the developed model shows that the model is capable of predicting the compaction behaviour of pharmaceutical materials since it fits the experimental data accurately.en_US
dc.language.isoenen_US
dc.subjectPDE methoden_US
dc.subjectParametric surfacesen_US
dc.subjectAxisymmetric deformationen_US
dc.subjectCompression and compactionen_US
dc.subjectHeckel modelen_US
dc.subjectREF 2014
dc.titleMethod of modelling the compaction behaviour of cylindrical pharmaceutical tabletsen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionNo full-text available in the repositoryen_US
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2010.12.006


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