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    Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol plus Water Mixtures at 298.2 K

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    Publication date
    2010-01
    Author
    Ali, Hany S.M.
    York, Peter
    Blagden, Nicholas
    Soltanpour, S.
    Acree, W.E. Jr.
    Jouyban, A.
    Keyword
    Solubility
    Crystal engineering
    Budesonide
    Hydrocortisone
    Prednisolone
    Ethanol and water mixtures
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Experimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum values of the volume fractions of 90 %, 80 %, and 80 % of ethanol. The Jouyban-Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 5.1 %, 6.4 %, 37.7 %, and 35.9 %, respectively, for the fitted model, the trained version for ethanol + water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities were also predicted by a previously established log-linear model of Yalkowsky with the OMRD of 53.8 %.
    URI
    http://hdl.handle.net/10454/4853
    Citation
    Ali, H.S.M., York, P., Blagden, P., Soltanpour, S., Acree, Jr., W.E. and Jouyban, A. (2010). Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol plus Water Mixtures at 298.2 K. Journal of Chemical and Engineering Data. Vol. 55, No. 1, pp. 578-582.
    Link to publisher’s version
    http://dx.doi.org/10.1021/je900376r
    Type
    Article
    Collections
    Life Sciences Publications

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