Show simple item record

dc.contributor.authorOsman, Ilham F.*
dc.contributor.authorBaumgartner, Adolf*
dc.contributor.authorAnderson, Diana*
dc.contributor.authorCemeli, Eduardo*
dc.contributor.authorFletcher, Jonathan N.*
dc.date.accessioned2011-02-03T15:43:28Z
dc.date.available2011-02-03T15:43:28Z
dc.date.issued2010
dc.identifier.citationOsman, I. F., Baumgartner, A., Cemeli, E., Fletcher, J. N. and Anderson, D. (2010). Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells. Nanomedicine. Vol. 5, No. 8, pp. 1193¿1203.en_US
dc.identifier.urihttp://hdl.handle.net/10454/4776
dc.descriptionyesen_US
dc.description.abstractAims: The rapidly growing industrial and medical use of nanomaterials, especially zinc oxide and titanium dioxide, has led to growing concerns about their toxicity. Accordingly, the intrinsic genotoxic and cytotoxic potential of these nanoparticles have been evaluated. Materials & methods: Using a HEp-2 cell line, cytotoxicity was tested along with mitochondrial activity and neutral red uptake assays. The genotoxic potential was determined using the Comet and the cytokinesis-blocked micronucleus assays. In addition,tyrosine phosphorylation events were investigated. Results & conclusion: We found concentration- and time-dependent cytotoxicity and an increase in DNA and cytogenetic damage with increasing nanoparticle concentrations. Mainly for zinc oxide, genotoxicity was clearly associated with an increase in tyrosine phosphorylation. Our results suggest that both types of nanoparticles can be genotoxic over a range of concentrations without being cytotoxic.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.2217/nnm.10.52en_US
dc.subjectNanoparticlesen_US
dc.subjectZinc oxideen_US
dc.subjectTitanium dioxideen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectHEp-2 cellsen_US
dc.subjectREF 2014en
dc.titleGenotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells.en_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.date.EndofEmbargo01/11/2011
dc.type.versionAccepted Manuscripten_US
dc.description.publicnotesEmbargo ended 3/11/ 2011en
refterms.dateFOA2018-07-18T13:09:39Z


Item file(s)

Thumbnail
Name:
Osman et al 2010 final draft ...
Size:
214.5Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record