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    Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells.

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    Osman et al 2010 final draft manuscript.pdf (214.5Kb)
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    Publication date
    2010
    End of Embargo
    01/11/2011
    Author
    Osman, Ilham F.
    Baumgartner, Adolf
    Anderson, Diana
    Cemeli, Eduardo
    Fletcher, Jonathan N.
    Keyword
    Nanoparticles
    Zinc oxide
    Titanium dioxide
    Cytotoxicity
    Genotoxicity
    HEp-2 cells
    REF 2014
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Aims: The rapidly growing industrial and medical use of nanomaterials, especially zinc oxide and titanium dioxide, has led to growing concerns about their toxicity. Accordingly, the intrinsic genotoxic and cytotoxic potential of these nanoparticles have been evaluated. Materials & methods: Using a HEp-2 cell line, cytotoxicity was tested along with mitochondrial activity and neutral red uptake assays. The genotoxic potential was determined using the Comet and the cytokinesis-blocked micronucleus assays. In addition,tyrosine phosphorylation events were investigated. Results & conclusion: We found concentration- and time-dependent cytotoxicity and an increase in DNA and cytogenetic damage with increasing nanoparticle concentrations. Mainly for zinc oxide, genotoxicity was clearly associated with an increase in tyrosine phosphorylation. Our results suggest that both types of nanoparticles can be genotoxic over a range of concentrations without being cytotoxic.
    URI
    http://hdl.handle.net/10454/4776
    Version
    Accepted Manuscript
    Citation
    Osman, I. F., Baumgartner, A., Cemeli, E., Fletcher, J. N. and Anderson, D. (2010). Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells. Nanomedicine. Vol. 5, No. 8, pp. 1193¿1203.
    Link to publisher’s version
    http://dx.doi.org/10.2217/nnm.10.52
    Type
    Article
    Notes
    Embargo ended 3/11/ 2011
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    Life Sciences Publications

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