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dc.contributor.authorOrtner, D.J.
dc.contributor.authorPonce, P.
dc.contributor.authorOgden, Alan R.
dc.contributor.authorBuckberry, Jo
dc.date.accessioned2011-01-12T12:20:10Z
dc.date.available2011-01-12T12:20:10Z
dc.date.issued2010
dc.identifier.citationOrtner, D. J., Ponce, P., Ogden, A. and Buckberry, J. (2010). Multicentric osteosarcoma associated with DISH, in a 19th Century burial from England. International Journal of Osteoarchaeology. DOI: 10.1002/oa.1196 [First published online 4th Aug 2010].en
dc.identifier.urihttp://hdl.handle.net/10454/4677
dc.descriptionnoen
dc.description.abstractOsteosarcoma is a rare type of malignant neoplasm that is most frequent in adolescents and young adults although it can develop at any age. It can metastasize from a primary site in bone to other bones and soft tissues. Usually the disorder causes a single bone-forming lesion (unicentric) but some cases have multicentric, bone-forming lesions. Some of these lesions develop at different sites at different times. In a second variant of multicentric osteosarcoma, synchronous bone-forming lesions develop at multiple sites. Distinguishing between these two types of multicentric osteosarcoma is challenging in a clinical context and the criteria for doing so are unlikely to be met in an archaeological burial. Wolverhampton burial HB 39 was excavated from an early-nineteenth century cemetery site in England. It consists of the incomplete skeleton of an adult male of at least 45 years of age with multicentric osteosarcoma. The individual represented by this burial also had diffuse idiopathic skeletal hyperostosis (DISH). Three of the bone-forming lesions associated with osteosarcoma developed on the bony outgrowths related to DISH.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1002/oa.1196en
dc.subjectMulticentric osteosarcomaen
dc.subject19th Century burialen
dc.subjectPaleopathologyen
dc.subjectEnglanden
dc.subjectDiffuse Idiopathic Skeletal Hyperostosis (DISH)en
dc.subjectBone-forming lesionsen
dc.subjectSkeletal remainsen
dc.titleMulticentric osteosarcoma associated with DISH, in a 19th Century burial from England.en
dc.status.refereedYesen
dc.typeArticleen


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