Show simple item record

dc.contributor.authorGhosh, Nandita
dc.contributor.authorSheldrake, Helen M.
dc.contributor.authorSearcey, M.
dc.contributor.authorPors, Klaus
dc.date.accessioned2010-12-23T12:42:28Z
dc.date.available2010-12-23T12:42:28Z
dc.date.issued2009-10
dc.identifier.citationGhosh, N., Sheldrake, H. M., Searcey, M. and Pors, K. (2009). Chemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products. Current Topics in Medicinal Chemistry, Vol. 9, No. 16, pp. 1494-1524.en
dc.identifier.urihttp://hdl.handle.net/10454/4646
dc.descriptionyesen
dc.description.abstractCC-1065, the duocarmycins and yatakemycin are members of a family of ultrapotent antitumour antibiotics that have been the subject of extensive investigations due to their mode of action and potential in the design of new anticancer therapeutics. The natural products and their analogues exert their effects through a sequence selective alkylation of duplex DNA in the minor groove at the N3 of adenine. An understanding of their structure and its effect on biological activity has been derived through chemical synthesis and has also generated new potential lead compounds. These studies form the first section of the review. The desire to progress these compounds to clinic has also led to studies of bioconjugation and prodrug formation and this is discussed in the second section of the review. The combination of synthesis with key biological experiments is a powerful tool to define the requirements for the development of natural products as potential therapeutic agents. The studies described herein form an excellent paradigm for the study and development of other natural products.en
dc.description.sponsorshipEPSRC, Yorkshire Cancer Research, Big C Cancer Research, UCB Pharmaen
dc.language.isoenen
dc.publisherBenthamen
dc.relation.isreferencedbyhttp://www.bentham.org/ctmc/contabs/ctmc9-16.htmen
dc.rights© 2009. Bentham Science Publishers. Reproduced in accordance with the publisher's self-archiving policy.en
dc.subjectDuocarmycinen
dc.subjectAnti-tumour antibioticsen
dc.subjectCC-1065en
dc.subjectAadozelesinen
dc.subjectCBIen
dc.subjectCPIen
dc.subjectDNA minor groove binders (MGBs)en
dc.subjectAdenine N3 alkylationen
dc.subjectProdrugsen
dc.subjectAnti-cancer therapeuticsen
dc.subjectNatural productsen
dc.titleChemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionAccepted Manuscripten
refterms.dateFOA2018-07-18T00:00:31Z


Item file(s)

Thumbnail
Name:
CTMC Review [KPors HMS revised ...
Size:
604.2Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record