Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.
dc.contributor.author | Stavri, M. | * |
dc.contributor.author | Matthew, K.T. | * |
dc.contributor.author | Gordon, Andrew | * |
dc.contributor.author | Shnyder, Steven | * |
dc.contributor.author | Falconer, Robert A. | * |
dc.contributor.author | Gibbons, S. | * |
dc.date.accessioned | 2010-12-21T16:40:49Z | |
dc.date.available | 2010-12-21T16:40:49Z | |
dc.date.issued | 2008-03-17 | |
dc.identifier.citation | Stavri M, Matthew KT, Gordon A et al (2008) Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.. Phytochemistry. 69(9): 1915-1918. | en |
dc.identifier.uri | http://hdl.handle.net/10454/4618 | |
dc.description | No | en |
dc.description.abstract | A phytochemical study of the asteraceous herb Pulicaria crispa (Forssk.) Oliv. resulted in the characterisation of three guaianolide sesquiterpenes, 2α,4α-dihydroxy-7αH,8αH,10αH-guaia-1(5),11(13)-dien-8β,12-olide (1), 1α,2α-epoxy-4β-hydroxy-5αH,7αH,8αH,10αH-guaia-11(13)-en-8β,12-olide (2) and 5,10-epi-2,3-dihydroaromatin (3). The structures were assigned on the basis of extensive 1 and 2D NMR experiments. Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8 ± 0.2 μM) in a human bladder carcinoma cell line, EJ-138. | en |
dc.language.iso | en | en |
dc.subject | Sesquiterpene | en |
dc.subject | Guaianolide | en |
dc.subject | Pulicaria Crispa | en |
dc.subject | Mycobacterium | en |
dc.subject | Pseudoguaianolide | en |
dc.title | Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv. | en |
dc.status.refereed | Yes | en |
dc.type | Article | en |
dc.type.version | No full-text in the repository | en |
dc.identifier.doi | https://doi.org/10.1016/j.phytochem.2008.03.012 |