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    The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases.

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    Publication date
    2009
    Author
    Rhodes, L.E.
    Gledhill, Karl
    Masoodi, Mojgan
    Haylett, A.K.
    Brownrigg, M.
    Thody, Anthony J.
    Tobin, Desmond J.
    Nicolaou, Anna
    Keyword
    Hydroxyeicostetraenoic acids
    Prostaglandins
    Tandem mass spectrometry
    Cyclooxygenase
    Lipoxygenase
    Leucocytes
    Sunburn response
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Sunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV) B-induced hydrolysis of membrane phospholipids releases polyunsaturated fatty acids and their subsequent metabolism by cyclooxygenases (COX) and lipoxygenases (LOX) may produce potent eicosanoid mediators modulating different stages of the inflammation. Our objective was to identify candidate eicosanoids formed during the sunburn reaction in relation to its clinical and histological course. We exposed skin of healthy humans (n=32) to UVB and for 72h examined (i) expression of pro- and anti-inflammatory eicosanoids using LC/ESI-MS/MS and (ii) immunohistochemical expression of COX-2, 12-LOX, 15-LOX and leucocyte markers, while (iii) quantifying clinical erythema. We show that vasodilatory prostaglandins (PG)E2, PGF2¿ and PGE3 accompany the erythema in the first 24-48h, associated with increased COX-2 expression at 24h. Novel, potent leukocyte chemoattractants 11-, 12- and 8-monohydroxy-eicosatetraenoic acid (-HETE) are elevated from 4-72h, in association with peak dermal neutrophil influx at 24h, and increased dermal CD3+ lymphocytes and 12- and 15-LOX expression from 24-72h. Anti-inflammatory metabolite 15-HETE shows later expression, peaking at 72h. Sunburn is characterized by overlapping phases of increases in COX products followed by LOX products that may regulate subsequent events and ultimately its resolution.
    URI
    http://hdl.handle.net/10454/4586
    Version
    published version paper
    Citation
    Rhodes, L. E., Gledhill, K., Masoodi, M., Haylett, A. K., Brownrigg, M., Thody, A. J., Tobin, D. J. and Nicolaou, A. (2009). The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases. FASEB Journal, Vol. 23, No.11, pp. 3947¿3956.
    Link to publisher’s version
    http://dx.doi.org/10.1096/fj.09-136077
    Type
    Article
    Collections
    Life Sciences Publications

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