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dc.contributor.authorKelly, L.E.
dc.contributor.authorGrehan, B.
dc.contributor.authorChiesa, A.D.
dc.contributor.authorO'Mara, S.M.
dc.contributor.authorDowner, E.
dc.contributor.authorSahyoun, George
dc.contributor.authorMassey, Karen A.
dc.contributor.authorNicolaou, Anna
dc.contributor.authorLynch, M.A.
dc.date.accessioned2010-12-15T16:25:03Z
dc.date.available2010-12-15T16:25:03Z
dc.date.issued2010
dc.identifier.citationKelly, L., Grehan, B., Chiesa, A. D., O'Mara, S. M., Downer, E., Sahyoun, G., Massey, K. A., Nicolaou, A. and Lynch, M. A. (2010). The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat. Neurobiology of Aging. [Article in press, 15/12/2010]. DOI: 10.1016/j.neurobiolaging.2010.04.001en
dc.identifier.urihttp://hdl.handle.net/10454/4583
dc.descriptionnoen
dc.description.abstractAge is characterized by deficits in synaptic function identified by decreased performance of aged animals in spatial learning tasks and reduced ability of animals to sustain long-term potentiation (LTP). Several cellular and molecular events are correlated with these deficits, many of which are indicative of cell stress. Thus there is evidence of age-related neuroinflammatory stress and oxidative stress and these have been linked with microglial activation which is likely to be primarily responsible for the age-related increase in production of proinflammatory cytokines and reactive oxygen species. It is significant that agents which decrease microglial activation are commonly associated with restoration of function. We set out to examine whether the n-3 polyunsaturated fatty acid docosapentaenoic acid (DPA), which is a metabolite of eicosapentaenoic acid (EPA), could modulate the age-related increase in microglial activation and the associated increase in oxidative changes and therefore impact on synaptic function in aged rats. We demonstrate that DPA possesses neurorestorative effects and is capable of downregulating microglial activation. The data show that it also decreases the coupled activation of sphingomyelinase and caspase 3, probably as a result of its ability to decrease age-related oxidative changes, and consequently attenuates the age-related decrease in spatial learning and LTP.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.04.001en
dc.subjectAge and agingen
dc.subjectHippocampusen
dc.subjectSynaptic functionen
dc.subjectLong term potentiation (LTP)en
dc.subjectPolyunsaturated fatty acidsen
dc.subjectCeramideen
dc.subjectReactive oxygen speciesen
dc.subjectSpatial learningen
dc.titleThe polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged raten
dc.status.refereedyesen
dc.typeArticleen
dc.identifier.JournalTitleNeurobiology of Agingen


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