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dc.contributor.authorMasoodi, Mojgan*
dc.contributor.authorNicolaou, Anna*
dc.contributor.authorGledhill, Karl*
dc.contributor.authorRhodes, L.E.*
dc.contributor.authorTobin, Desmond J.*
dc.contributor.authorThody, Anthony J.*
dc.date.accessioned2010-12-15T15:41:18Z
dc.date.available2010-12-15T15:41:18Z
dc.date.issued2010
dc.identifier.citationMasoodi, M., Nicolaou, A., Gledhill, K., Rhodes, L. E., Tobin, D. J. and Thody, A. J. (2010). Prostaglandin D2 production in FM55 melanoma cells is regulated by ¿-melanocyte-stimulating hormone and is not related to melanin production. Experimental Dermatology, Vol. 19, No. 8, pp. 751¿753.
dc.identifier.urihttp://hdl.handle.net/10454/4581
dc.descriptionNo
dc.description.abstractThis study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. ¿-Melanocyte stimulating hormone (¿-MSH), which had no effect on melanin production in FM55 cells, stimulated PGD2 production in these cells without affecting PGE2. While cAMP pathways may be involved in regulating PGD2 production, our results suggest that ¿-MSH acts independently of cAMP, possibly by regulating the activity of lipocalin-type PGD synthase. This ¿-MSH-mediated effect may be associated with its role as an immune modulator.
dc.description.sponsorshipThe Wellcome Trust
dc.language.isoen
dc.subjectProstaglandin D2
dc.subjectPigment cells
dc.subject¿-melanocyte stimulating hormone
dc.subjectMelanogenesis
dc.subjectLiquid Chromatography Electrospray Tandem Mass Spectrometry (LC/ESI/MS)
dc.titleProstaglandin D2 production in FM55 melanoma cells is regulated by ¿-melanocyte stimulating hormone and is not related to melanin production.
dc.status.refereedYes
dc.typeArticle
dc.identifier.JournalTitleExperimental Dermatologyen
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1111/j.1600-0625.2010.01098.x
dc.openaccess.statusclosedAccess


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