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    Prostaglandin D2 production in FM55 melanoma cells is regulated by ¿-melanocyte stimulating hormone and is not related to melanin production.

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    Publication date
    2010
    Author
    Masoodi, Mojgan
    Nicolaou, Anna
    Gledhill, Karl
    Rhodes, L.E.
    Tobin, Desmond J.
    Thody, Anthony J.
    Keyword
    Prostaglandin D2
    Pigment cells
    ¿-melanocyte stimulating hormone
    Melanogenesis
    Liquid Chromatography Electrospray Tandem Mass Spectrometry (LC/ESI/MS)
    Peer-Reviewed
    yes
    
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    Abstract
    This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. ¿-Melanocyte stimulating hormone (¿-MSH), which had no effect on melanin production in FM55 cells, stimulated PGD2 production in these cells without affecting PGE2. While cAMP pathways may be involved in regulating PGD2 production, our results suggest that ¿-MSH acts independently of cAMP, possibly by regulating the activity of lipocalin-type PGD synthase. This ¿-MSH-mediated effect may be associated with its role as an immune modulator.
    URI
    http://hdl.handle.net/10454/4581
    Citation
    Masoodi, M., Nicolaou, A., Gledhill, K., Rhodes, L. E., Tobin, D. J. and Thody, A. J. (2010). Prostaglandin D2 production in FM55 melanoma cells is regulated by ¿-melanocyte-stimulating hormone and is not related to melanin production. Experimental Dermatology, Vol. 19, No. 8, pp. 751¿753.
    Link to publisher’s version
    http://dx.doi.org/10.1111/j.1600-0625.2010.01098.x
    Type
    Article
    Collections
    Life Sciences Publications

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